Martial missed the win over Watford with an ankle injury while Rooney was suffering from illness but both are expected to come straight back in to the side tomorrow night.
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Anthony Martial, Michael Carrick, Marouane Fellaini, Ander Herrera, James Wilson, Phil Jones and Juan Mata are all injury doubts, while Luke Shaw and Antonio Valencia are out long-term.
But subsequent home wins over Wolfsburg (six points) and CSKA Moscow (four points), as well as a 1-1 draw in Moscow, have taken them to the top of the group.
PSV supporters were also left horrified by the injury, which he suffered in a challenge from the Dutch side’s Mexican defender Hector Moreno.
The Manchester United and England captain, who turned 30 last month, has struggled for goals despite his club’s fine start to the season, netting just twice in 11 Premier League fixtures.
But left-back Shaw has been spared a reunion with PSV as he continues his recovery from the double leg break he sustained in United’s 2-1 defeat in Eindhoven in September, which was their opening Group B game. “I am the type of coach who does not demand one good match but several matches”, said Van Gaal.
But Van Gaal, who previously managed Mexico global Moreno at AZ Alkmaar, insists there is no question of his players seeking retribution.
“I think some games we did not score a lot of goals but created chances and maybe if you don’t see the game you think it is boring”, he said.
Nick Powell is continuing to work his way back to full fitness after training with Manchester United’s first-team squad ahead of the Champions League clash with PSV Eindhoven.
“I think how we played was the same system as I played with the Dutch national team, and then he (Depay) has more freedom and these players are so happy with that freedom they can excel and he showed that in the first half”, Van Gaal said.
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He said the 20-year-old was responding well, but added: ‘You have to be very cautious with an injury like that. Not only because of the result, but also because of the loss of Luke Shaw. It is always a decision of the manager.
