Wawrinka hit back but at two sets to one down and with the score at 2-2 in the fourth the world number four faced two break points.
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Roger Federer misses out injured, but Rafa Nadal, Andy Murray and defending champ Stan Wawrinka are all here.
Serbia’s Janko Tipsarevic was playing Roland Garros for the first time since 2013.
In the second round, Wawrinka might have a less stressful engagement against the American-based Japanese Davis Cupper, Taro Daniel, who came from two sets down to beat the experienced Slovakian clay-courter, Martin Klizan, on a retirement when leading 3-6, 4-6, 7-5, 6-4, 3-0 on Court No4.
Simona Halep, beaten by the now suspended Maria Sharapova in the 2014 final, made short work of her opener, dropping only two games against Japan’s Nao Hibino.
“I got 10 matches out of two weeks, which is maximum I could get out of Madrid and Rome, and it was a ideal way of getting the match play that I needed before French Open”, Djokovic said.
Rosol refused to buckle when dropping the second set, racing to a 3-0 lead in the third.
Tenth-seeded former US Open champion Marin Cilic, however, suffered his earliest loss at a Slam in five years when Argentine qualifier Marco Trungelliti clinched a shock 7-6 (4), 3-6, 6-4, 6-2 win.
“Hopefully, I can just compete as hard as I can, and that’s really it”, Fratangelo recently told the Post-Gazette in an interview.
Stan Wawrinka, the defending champion at Roland Garros, was pushed to five sets against his opening round opponent on Monday.
“I need to be ready to suffer a little bit during the match, because I know it’s going to be hard to have breaks”, Nadal said.
The world No 4 rattled through the second set to level and seemingly get back on track, but 59th-ranked Rosol appeared on course for a repeat of his stunning 2012 win over Rafael Nadal at Wimbledon when he moved ahead once more in the next set. It’s a good victory, he was playing really well and it wasn’t easy for me to get into the match.
On another rain-affected today, Japan’s fifth seed Kei Nishikori secured a 6-1, 7-5, 6-3 win over Simone Bolelli of Italy.
Djokovic has lost in the final on the red clay in three of the last four years.
Heavy rain delayed the start of play for almost two-and-a-half hours and Wawrinka, who beat Rosol on the way to winning the Geneva Open title at the weekend, clearly did not enjoy the conditions.
Spanish fourth seed Garbine Muguruza came back from a set down to defeat Slovakia’s Anna Karolina Schmiedlova 3-6, 6-3, 6-3 to reach the French Open second round.
Rain on day one had wiped out eight men’s matches and interrupted three more, while 22 of 32 women’s matches were incomplete. I was scared to play matches before Paris.
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– Main-draw match victories in Grand Slam history by Turkish women, after Cagla Buyukakcay earned the first by beating Aliaksandra Sasnovich of Belarus 5-7, 7-6 (2), 6-2 in the first round.
