Andre Agassi and Michael Russell both made it that far in 2001.
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Isner, the last American man in the draw, used 34 aces to beat 79th-ranked Teymuraz Gabashvili of Russian Federation 7-6, (7), 4-6, 2-6, 6-4, 6-2 on Friday.
Murray, a three-time Roland Garros semi-finalist, will play veteran big-serving Croat Ivo Karlovic for a place in the last 16.
However, the two-time major champion responded in the fourth to force a decider, and Murray completed a second straight nervy five-set win having been taken the distance by Radek Stepanek in the opening round.
The second-seeded Briton is trailing 2-1 in sets against French wild-card entry Mathias Bourgue, who is showing his vast array of shots on Court Philippe Chatrier with some superb drop shots and volleys.
Murray was down by two sets in the first round, then twice trailed by a set in the second.
Osaka also reached the third round in her first Grand Slam tournament, this year’s Australian Open. Connors was 39 when he progressed to the semifinals at Flushing Meadows that year.
Karlovic, the 27th seed, defeated Australian wildcard Jordan Thompson 6-7 (2/7), 6-3, 7-6 (7/3), 6-7 (4/7), 12-10 in a four and a half hour marathon.
Despite changing his French Open preparations to play the Geneva Open, Stan Wawrinka feels his form continues to improve. All in all, though, things went a lot more smoothly than in his opening match.
Defending French Open champion Stan Wawrinka yesterday avoided a repeat of his first-round scare, though he was still made to work hard in a straight-sets win over Japan’s Taro Daniel.
The third-seed recovered from the third-set break down to record a 7-6 (9-7), 6-3, 6-4 win over his Japanese opponent in a thrilling second round contest. “Today there were many ups and downs, but I have my tennis and I’m ready to step it up”.
Wawrinka compiled a 62-21 advantage in winners and will now face No. 30 Jeremy Chardy of France for a spot in the round of 16. But the milestone that really matters to Djokovic is winning his first French Open, the only Grand Slam he hasn’t won.
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Gasquet enjoyed a more comfortable victory over the subdued Nick Kyrgios, who appeared to be hampered by a shoulder problem in a 6-2 7-6 6-2 defeat to the Frenchman.
