A suicide bomber detonated an explosives belt inside a bus carrying rebels from Turkey into Syria through the Atmeh border crossing some 40 kilometres west of Aleppo, the Syrian Observatory for Human Rights said.
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The death toll was likely to rise, activists monitoring the conflict said.
Several explosions rocked near the Turkish borders throughout the Syrian crisis, as part of the rebel-on-rebel tension.
The rebels hit in the blast were rotating back into Syria to replace fighters returning from action, the Observatory said.
The Islamic State jihadist group on Monday claimed responsibility for a suicide bombing that killed more than 30 Syrian rebel fighters in a blast near the Turkish border.
Pictures circulating on social media, which have not been immediately verified by Reuters, showed the burnt out remains of a bus and medics treating injured people.
Idlib is a major bastion of the Turkey-backed opposition to President Bashar al-Assad’s rule.
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The fighting in Aleppo, once Syria’s commercial and industrial hub, has escalated in the past week, with the rebels severing the main route into the government-controlled west of the city.
