The strikes hit the Abs hospital in northern Hajjah province Monday afternoon, the group said via Twitter.
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MSF called on all parties, particularly the Saudi-led coalition which it blamed for the hospital attack, to guarantee that such attacks do not happen again.
The Saudi-led coalition has been carrying out airstrikes in Yemen since March 2015.
Border Guards Corporal Mishari al-Shahrani on Monday morning became the latest Saudi casualty, the Interior Ministry said.
The facility has been providing a range of services and medical aid for internally displaced people, along with emergency and maternal health care and surgery, the group said on its website.
The Saudi-led coalition acted in support of Yemen’s government against Houthi rebels and their allies who overran much of the country.
The coalition denied targeting a school, instead saying it bombed a camp at which rebels train underage soldiers.
The Saudi-led coalition, backing the government, commenced airstrikes in March 2015.
Residents and local officials told Reuters that at least seven people were killed and 13 others wounded, although NBC News was not immediately able to verify that information.
MSF, which operates in conflict zones around the world, has had a number of its facilities attacked over the past year.
In October previous year, more than 40 staff and patients were killed in a U.S. gunship raid on one of the charity’s hospitals in Afghanistan.
United Nations deputy spokesman Farhan Haq said the U.N.is trying to gather details on Monday’s attack.
Since peace talks collapsed nine days ago, the Saudi-led coalition has conducted hundreds of air raids in the Yemeni capital Sanaa and all over northern Yemen, killing at least 60 civilians.
Harad itself is seeing fierce fighting and is frequently a target of heavy coalition air strikes.
The United States and Amnesty International separately condemned the attack.
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Another air attack hit what MSF described as a school in neighbouring Saada province on Saturday, killing 10 children. “Continued military actions only prolong the suffering of the Yemeni people”.
