The five-alarm blaze started at about 6:10 p.m.in a three-story house on a crowded block on Benziger Ave. near Jersey St.in St. George.
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NYPD Aviation was assisting the FDNY in surveying the scene of the blaze with two choppers in the area.
Five firefighters experienced minor injuries that did not require going to the hospital as of 7:45 p.m., an FDNY spokesman said. It could also reportedly be seen from as far away as Manhattan. Firefighters, police, and representatives from Con Edison and the Office of Emergency Management remained on the scene.
Residents were advised to close their windows to avoid the smoke.
Firefighters are still working to contain the flames.
Fire officials say heat from the heavy fire melted siding on buildings across the street.
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Red Cross officials said Thursday night that 42 displaced individuals have been registered for assistance.
