The gas is thought to have been chlorine dropped in a barrel bomb, said the Syrian Civil Defence – volunteer emergency response workers who operate in opposition-held areas.
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The divided city of Aleppo has been rocked by escalating violence, with people on both sides living in fear of being trapped.
They said that in the past month there had been 42 attacks on medical facilities in Syria, 15 of them on hospitals where they work.
Two barrel bombs allegedly containing chlorine gas were dropped on 1 August in two residential neighbourhoods in the city of Saraqeb in Idleb province, reportedly injuring at least 28 civilians.
Rebels and jihadists broke a government siege over the weekend, allowing aid into Syria’s second city.
Shelling and strikes were reported on the rebel side of Aleppo on Thursday despite a temporary ceasefire announced by Russian Federation to clear the way for humanitarian envoys to reach civilians, activists said.
Russian forces in Syria have declared a three-hour daily halt to air strikes on Aleppo in order to let vital humanitarian aid to get in.
The Special Advisor to the UN Special Envoy to Syria, Jan Egeland, says they are waiting for the “all clear” to deliver the badly-needed supplies.
Aleppo, Syria’s most populous city before the war, continues to be the subject of an intense battle between rebels and Russian-backed Syrian government forces.
Clashes have been reported in and around the northern Syrian city of Aleppo despite efforts by Russian Federation to halt military action to allow in aid.
Since then, more than 250,000 people have been killed and more than 10 million displaced, according to the United Nations, which stopped counting two years ago.
Rebels and regime forces clashed in southern Aleppo throughout Thursday morning, said the Syrian Observatory for Human Rights.
But the pediatricians, surgeons, and other physicians who signed the letter said the situation remained dire. So far, other reports have counted at least 70 patients affected by the attack.
Experts have expressed concern that the use of chemical weapons is no longer as shocking as it was a few years ago.
“We do not need tears or sympathy or even prayers, we need your action. Prove that you are the friend of Syrians”, they wrote.
Hospital officials in Aleppo told the Reuters News Agency that four people, including women and children, were killed and another 55 suffered from breathing difficulties from poison gas, apparently chlorine.
Russian Federation said the raids destroyed a “chemical weapons factory” on Raqqa’s outskirts as well as a weapons storage facility and ISIL training camp to the north and south-east. But a resident of Aleppo told the BBC that there had not been a ceasefire on Thursday.
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If it was chlorine gas, this wouldn’t be the first timethe Syrian regime was accused of using chemicals in attacks that injured and killed civilians.
