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Broncos DE Wolfe leaves practice with ankle injury

And Jared Crick made his first start of the preseason at defensive end, in place of Vance Walker, who was put on injured reserve with a torn ACL this week.

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The 49ers second stringers gave the Broncos a run for their money, holding a lead for almost the entire second half.

After practice, Kaepernick, who met with Broncos general manager John Elway and Kubiak last spring about possibly coming to Denver in a trade, stopped to sign autographs for fans and even posed with one for a selfie. Kickoff is set for 9 p.m. ET from Sports Authority Field at Mile High.

With Trevor Siemian under center, the Broncos offense came out firing to begin the game.

Look for C.J. Anderson to get a huge workload as the Broncos double down on Gary Kubiak’s run-heavy schemes this year. Kaepernick warmed up with 10-yard passes before progressing to 15 and 25 yards. Siemian finished 10 of 14 for only 75 yards and the interception.

-The 49ers had two days of joint practice sessions with the Broncos leading into Saturday’s game, which gave Kelly and his coaching staff an opportunity to move some pieces around in their unsettled offensive line. Following the pick, Siemian did not look as composed in the pocket and his touch was not as precise.

It’s not often that you rack up 409 yards as a team, 302 in the first half, and not win the game. In talking to him, he said he feels really good about it. Unfortunately he made the wrong one. And then, Sanchez pulled a Sanchez and coughed up the ball up again. “A lot of things going on, a lot of competition”. “I just watch their decision-making process and those types of things”.

“I felt like that fits into my strong suit”, Lynch said, “so whenever he calls plays like that, I’ve just got to show that I can be trusted”.

Expect the Denver Broncos’ quarterback competition to continue into the third preseason game without a clear frontrunner.

Their defense allowed an opening-drive touchdown. The pass-rush was consistent and in the QB’s face from the start and the defensive backs were excellent in coverage. NaVorro Bowman rushed up the gut for a sack in the first quarter. “I think that I’ll get a chance to get reps in whenever they come and I’ll make the majority”. He allowed two receptions but was on the field throughout the first half. After about 50 passes, Kaepernick threw several deep passes to Ellington (including a perfectly placed 55-yard throw) in what appeared to be a scripted workout. The Broncos were interested in him, to a point.

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Colin Kaepernick, who has not been throwing any passes in practice since Thursday because of tightness in his right shoulder, was on the practice field for mental reps and took three running-play snaps, handing off every time. After jumping out to a 13-7 halftime lead, the offense stalled and San Fran wouldn’t score for the rest of the game.

Aug 20 2016 Denver CO USA Denver Broncos quarterback Trevor Siemian looks over center Matt Paradis and tackle Michael Schofield at the line of scrimmage in the first quarter against the San Francisco 49ers at Sports Authority Field