He said he hurt his left wrist a few days before the start of the Olympics, where he lost in the first round to Juan Martin del Potro.
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Third seeded Spaniard Muguruza, who has struggled in the aftermath of her Roland Garros breakthrough in June, slumped to a 7-5, 6-4 loss to Latvia’s Anastasija Sevastova, the world number 48.
Isner had a chance to close out the victory in the third-set tiebreaker but wasted four match points.
In a mild upset in the women’s draw, Denmark’s Caroline Wozniacki, a former world No. 1 and the 2009 and 2014 U.S. Open finalist, defeated 2004 champion Svetlana Kuznetsova of Russian Federation, the No. 9 seed, 6-4, 6-4.
The U.S. Open remains the only major at which Kvitova has yet to reach at least the semifinals, but maybe she’s started to figure out her annual trip to the Big Apple: Just don’t practice.
Christian departed in the opening round and according to the rankings and the script, world number 120 Ryan was supposed to follow his brother to the exit gate on Wednesday after his second-round match against fifth seed Milos Raonic.
“It was extremely physical out there”.
The 24-year-old American, who beat Raonic once in their previous two meetings, came prepared to give the sixth-ranked Canadian a battle and proved the more durable during a three hour, 37 minute match played in sweltering conditions. He wound up with 18 aces but 15 double faults and a whopping 62 unforced errors – too many at the net.
The pressure of the moment, combined with the fact his serve wasn’t as sharp as it usually is, conspired against Raonic creating the cramping issues. There was a lot of nerves and stress. “It was a result of over-exuberance”, said 25-year-old Raonic who claimed that the pain eventually spread to his back and arms and that, as a result, he was unable to carry his bags.
Earlier Wednesday, Djokovic advanced to the third round by walkover when his opponent, Czech Jiri Vesely, withdrew from the tournament with a left forearm injury.
A former No. 1, Wozniacki is now ranked 74th after dealing with an ankle injury and a series of losses. “The first two sets, when you have a crowd behind you like that, you’re just playing on adrenaline”. I just felt a little bit a step slow. Nadal obliged, but couldn’t get the ball far enough, then said with a smile: “Impossible for me”. “I was just sort of trying to get through, either hope it subsides after a certain amount of time or gets better”.
Johanna Konta, the tournament’s 13th-seeded woman, collapsed and received medical treatment right out there on Court 13 late in the second set of her 6-2, 5-7, 6-2 victory over Tsvetana Pironkova.
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Britain’s Kyle Edmund backed up his first round win over world number 15 Richard Gasquet with a 7-5, 6-4, 6-4 victory over United States wildcard Ernesto Escobedo on the back of 53 winners.
