At the start of the third, however, he called on the trainer to massage his troublesome right elbow and there was some temporary respite for Edmund, who broke twice to lead 3-2.
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In between, Edmund eased past the United States’ in-form wildcard Ernesto Escobedo in straight sets.
The bottom half of the women’s last 16 will be played out with second seeded Australian Open champion Angelique Kerber facing two-time Wimbledon victor Petra Kvitova.
“I do know her and I have been on court with her”, Konta said.
The 26th-seeded Sock upset 2014 U.S. Open champ Marin Cilic in the third round, never facing a break point.
Then, from 2-0 down in the third set, the 21-year-old fought back.
And while Youzhny has not so much as reached the final of a tournament since 2013, and slipped to 153 at the end of previous year, he began 2016 with three straight Challenger titles, before illness and a hamstring pull marred his season.
Djokovic will now meet Jo-Wilfried Tsonga on Tuesday in his quarter-final, once more looking on course for a clash with Murray for the title.
The seventh-seeded Italian beat 99th-ranked Lesia Tsurenko 7-6 (5), 6-2 on Sunday.
Jo-Wilfired Tsonga has been an enigma in the world of tennis, having the talent and ability to reach the top but that he is yet to win a major Grand Slam shows how inconsistent he has been.
Anderson upset Andy Murray in the fourth round past year at Flushing Meadows, but he’s struggled with injuries this season.
For those first two sets, it was as one-sided as it gets in a round-of-16 major tie.
She made her first major final here past year at age 32, stunning Serena Williams in the semis to thwart the American’s Grand Slam bid. During the match, Đoković won just as his opponent three points directly from the serve, committed seven double mistakes and the first service percentage was 61 percent. Then Vinci won the last three games to move on.
It means the 21-year-old has reached the fourth round of a grand slam for the first time and his reward is a showdown with Djokovic, the 12-time major champion and top seed in NY.
So his opening match against the big-hitting Jerzy Janowicz was watched with great interest. The Latvian also made it that far at the 2011 Australian Open, but in May 2013, she retired after a series of injuries.
Edmund had said earlier he was prepared for a five-setter if needed, but clearly he was straining to finish it in four – while Isner continued to play his unique brand of attritional tennis. But she returned to the sport at the start of last season, and her ranking has steadily climbed to 48th.
The US Open is tennis’ most generous tournament in terms of its pay outs to athletes, with this year’s singles winners due to earn a record $3.5m.
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Djokovic also had his right arm worked on during his first-round win but got a chance to let that arm sit idle with a walkover in the second round and an early retirement in the third. It was his first night session on the biggest stadium and he made a lot of errors. However, next up is second seed Angelique Keber for a place in the semis.
