Bayer Leverkusen were trailing 1-0 from their first leg at Lazio, but made the most of home advantage in the return against their 10-man opponents.
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“We knew he had talent”, Valencia coach Nuno Espirito Santo said about the 23-year-old Ryan. “I wasn’t anxious. It is early days and when the chances came I took them”.
United missed out on the Champions League last season as a effect of its terrible season in 2013-14 under David Moyes, the successor to long-time manager Alex Ferguson.
Heading into the final leg, FC Astana hold a slight 1-0 aggregate lead over APOEL.
Now APOEL have their backs against the wall and should try to turn the tide around or their European campaign will end one round short of the group stages.
Louis van Gaal has managed to restore England’s most successful club to Europe’s top competition at the first attempt – albeit through the playoffs – as Bruges proved a soft touch on Wednesday.
Memphis Depay shone on his European debut for United with two goals in the first leg, while Marouane Fellaini added a late third to secure a two-goal cushion.
There was a second-leg comeback in Moscow, meanwhile, as CSKA mounted a stunning revival against Sporting.
With a 1-0 lead from the first leg, Igor Stasevich put BATE in control of the tie, although Maksim Zhavnerchik’s own goal and Ivan Saponjic’s strike for Partizan ensured a nervous finale for BATE in Belgrade before it progressed on away goals.
Partizan are without midfielder Marko Jevtovic for Wednesday’s crucial match after the player was sent off in the opening leg.
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Mikhail Gordeichuk’s goal gave BATE the edge in Belarus.
