The Red Devils crashed out of the competition after United captain Wayne Rooney and his England colleagues Michael Carrick and Ashley Young missed their spot-kicks in the penalty shootout.
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Manchester United face Middlesbrough in the League Cup but Morgan Schneiderlin says they will not take the match lightly.
Wilfried Bony headed City in front from Aleksandar Kolarov’s 22nd-minute corner before Kelechi Iheanacho teed up Kevin De Bruyne to tap in his sixth goal in nine club games shortly before half-time. But Juergen Klopp finally celebrated his first victory as Liverpool manager following three draws, with his new team advancing in the cup by beating Bournemouth 1-0 on Wednesday.
United became the latest high-profile casualty in the fourth round after Tuesday night saw Arsenal knocked out by second-tier Sheffield Wednesday and Chelsea beaten by Stoke City.
Chances were at a premium in extra time, as George Friend fired wide from 30 yards in the first period, before Pereira did similar from the outside of the Middlesbrough box after the break.
United substitute Anthony Martial had a penalty shout for handball rejected and went close with a header in extra time, and the home side were left to rue their missed opportunities.
That next game comes at Crystal Palace on Saturday, with Van Gaal adamant that United’s recent run of troubles in front of goal will have no adverse effect on his players. “We have to solve this problem, we have to finish our chances”.
I’m pleased with a few of the performances of my players but I am also disappointed with a few of my players.
Meanwhile, Aston Villa began life without sacked manager Tim Sherwood by losing 2-1 at Premier League rivals Southampton, who won courtesy of goals by Maya Yoshida and Graziano Pelle.
“For that reason, I have to say how proud I am of my players”.
“It’s better than a draw”, Klopp told Sky Sports at Anfield with a wry smile.
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“We want to win this cup”. The goal is the most important thing in football and we didn’t do it. “To win is always good for the feeling of the whole team”. Against Manchester City, we were also not lucky but I can not repeat that every week that we’re not lucky.
