The two passenger trains collided head-on shortly after 7am (local time) in Bavaria, website BR24 reported.
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Dozens of rescue teams were on site, including helicopters, and streets in the area were closed.
Spokesman Stefan Sonntag said the scene was still so confusing that it was hard to put an exact number on the casualties, adding: “This is the biggest accident we have had in years in this region and we have many emergency doctors, ambulances and helicopters on the scene”.
Two trains have crashed head-on in southern Germany, killing at least four people.
The cause of the accident is not yet clear.
One of the trains was derailed in the crash and several carriages were overturned, German media reported.
At least four people are dead and another 150 injured, 10 of them seriously, after two commuter trains collided head on near the southern German town of Bad Aibling.
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The reason for the crash is not yet known and rescue workers are at the scene.
