The agreement was announced on Saturday by US Secretary of State John Kerry who said he had reached the deal with his Russian counterpart Sergei Lavrov that seeks ceasefire all over Syria.
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It also promises improved humanitarian aid access and joint military targeting of banned Islamist groups.
Forty days of fighting in Aleppo has killed almost 700 civilians, including 160 children, according to a Syrian human rights group.
Locals said they believed the jets that launched the strikes were Russian.
“The market was full of shoppers going to buy presents for their kids, they were all civilians”, civil defence worker Salem Idlibi said, adding the market was unusually busy ahead of a major Muslim feast on Monday.
Aleppo was also hit from the air and fighting continued on the ground.
The airstrikes targeted several areas in Idlib, mainly the Jisr al-Shughour area largely under the control of the rebels’ Jaish al-Fateh, or Army of Conquest, Xinhua quoted the Syrian Observatory for Human Rights as saying.
But mainstream opposition fighters have not indicated a willingness to break their alliance with powerful hardliners, which they view as “a military necessity”, according to Syria expert Charles Lister.
Numerous players – especially President Bashar Assad and his allies, Russia, Iran and Hezbollah – are scrambling as the clock runs out on the tenure of President Barack Obama, who has made clear that he will not significantly shift his Syria policy.
Syria has been mired in civil war since 2011, with government forces loyal to President Bashar Assad fighting numerous opposition factions and extremist groups, such as Jabhat Fatah al Sham and Daesh.
But, the High Negotiations Committee (HNC) said it feared that the Russian-U.S. deal would be enforced on the opposition to benefit the regime, the official spokesman of the HNC Riad Nassan Agha said.
In a sign of the multi-sided conflict, Israeli aircraft attacked a Syrian artillery post near the occupied Golan Heights on Saturday.
USA special envoy to the Syrian crisis Michael Ratney appealed to rebel groups to commit to the deal, saying it was the “best way” to save lives.
“This requires halting all attacks, including aerial bombardments, and any attempts to gain additional territory at the expense of the parties to the cessation”.
The ministry says Turkey will deliver aid through the United Nations to the Syrian city of Aleppo, which has seen heavy fighting in recent months.
Millions have fled the country, but almost 18 million people remain in Syria, which has been carved up by fighting between government and rebel forces.
“This all creates the necessary conditions for resumption of the political process, which has been stalling for a long time”, Mr Lavrov said.
Then, the US and Russian Federation would begin intelligence sharing and targeting coordination, while Assad’s air and ground forces would no longer be permitted to target the al-Qaida-linked militant group of Jabhat Fatah al-Sham, formerly known as the Nusra Front.
Getting Assad’s government and rebel groups to comply with the deal may now be more hard as fighting rages around Aleppo, Syria’s most populous city and the new focus of the war.
A new president could, theoretically, usher in a more active US role in the conflict. Syria’s conflict, now in its sixth year, has continued despite several rounds of peace talks and worldwide attempts to try end the violence.
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The announcement came after the Syrian government said it supports the U.S. -Russia agreement adding that it will cease its military operations in Aleppo.
