Mouse experiments showed that cancer patients who consume a lot of sugar have a higher risk of developing advanced cancer than patients who have a healthier diet.
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Their research showed at six months old, 30 per cent of those raised on starch-controlled diets had measurable tumours. University of Texas MD Anderson Cancer Center researchers have discovered that fructose boosts the growth of breast tumor, and helps it spread. “This indicates a possible signaling pathway responsible for sugar-promoted tumor growth in mice”. It is not that easy since not all sugars are from the same source and Glucose for example is a vital nutrient that is used by the body to create energy. The study results showed that starch was not as harmful as sugar in promoting cancer growth.
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Since sucrose is made up of fructose and glucose, the researchers wanted to see if these two types of sugar affected risk of cancer separately.
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Prof Cohen added: “This study suggests that dietary sucrose or fructose induced 12-LOX and 12-HETE production in breast tumour cells in vivo”.
Professor Lorenzo Cohen, a co-author of the study stated that the study had determined that fructose contained in table sugar and corn syrup with high fructose were specifically responsible. The team found that the more sucrose the mice ate, the larger the tumors became.
They fed mice four different diets that were either heavy in starch or heavy in different types of sugar.
“We found that sucrose intake in mice comparable to levels of Western diets led to increased tumour growth and metastasis, when compared to a non-sugar starch diet”. The mice were fed sugar everyday in doses that were carefully calculated so that they were as close to the levels of sugar that an American would eat every day.
Yang also noted that no other studies have explored the direct effect of sugar consumption on the development of breast cancer through animal models, or at least looked at the specific mechanisms involved. Corn syrup and table sugar were the other culprits contributing to the same risk.
In a press release, Dr. Lorenzo Cohen, a professor of palliative, rehabilitation, and integrative medicine at MD Anderson, said that the present study has investigated the effect of dietary sugar on mammary gland tumor development in a number of mouse models, along with mechanisms that could have involvement in it. “However, the inflammatory cascade may be an alternative route of studying sugar-driven carcinogenesis that warrants further study”.
The rise in obesity, heart disease and cancer worldwide has been blamed on the rising amount of sugar rich drinks people are consuming.
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A Western type of diet which typically includes a high intake of refined sugar including sucrose and fructose, according to the recent study, can lead not only to an increased risk of cavities but also to an increased risk of breast cancer.
