Pepper spray, which has become a familiar scent around the Trump campaign, was at one point used to push protesters back.
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Police outside the city’s convention centre ordered the crowd to disperse after the billionaire’s speech, but protesters from both sides refused to leave for hours.
A number of anti-Trump demonstrators threw water bottles and other objects at officers.
Chief Shelley Zimmerman, who was also on hand early, said there would be a “significant police presence”. CNN said that the Thursday delegate estimate for Trump was 1,237, while according to ABC America it was 1,239.
After the demonstration had largely dispersed, a woman was arrested for refusing to move as a police line advanced to clear the area.
“President (Barack) Obama came out of meetings with our closest allies in the world, and reporting that they are, quote, “rattled by the threat Donald Trump represent”.
As the Republican National Convention and likely coronation of Donald Trump as Republican presidential nominee approaches, the numbers of protestors showing up at Trump events have swelled.
Later, Trump appreciated the police for handling the “thugs”.
If his nomination is confirmed, Mr Trump will face former US Secretary of State Hillary Clinton or Vermont Senator Bernie Sanders, who are vying for the Democrat nomination. A second woman was later similarly arrested, also for unlawful assembly. San Diego’s population is about one-third Latino and hundreds of thousands of people cross the border with Mexico legally each day.
The provocative Republican has struggled to win the support of key figures in his party establishment, including House Speaker Paul Ryan, who have voiced concern about the presumptive nominee’s tone and his lack of policy specifics.
Protesters and supporters alike are encouraged to use public transportation to get to the event.
The Post reported that Curiel’s order to release an estimated 1000 pages of documents cites heightened public interest in Trump and that he had “placed the integrity of these court proceedings at issue”.
Protests in New Mexico turned violent on Tuesday, prompting fears of a similar outbreak of violence at Trump’s campaign appearances in California this week.
Donald Trump held a rally in San Diego, Calif. on Friday ahead of The Golden State’s primary in June.
About three-dozen people were arrested when anti-Trump demonstrators clashed with Trump supporters and police.
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She says officers will remain in the Gaslamp Quarter throughout the night.
