“All were under 15 years old”, the medical aid group said on its official Twitter account.
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Al-Alam News Network and Iran’s Tasnim news agency said some 50 school children were killed in the alleged strike, while local sources put the number at 9.
The group, known by the French acronym MSF, said the strike hit the hospital near the Houthi rebel stronghold of Saada, where teams were still attending to the wounded.
The report comes as the capital Sanaa and its surroundings have come under heavy bombardment by the Saudi-led military coalition battling Shiite rebels and their allies.
In June, the United Nations placed the Saudi coalition on a blacklist of states and armed groups that kill and maim children in war.
Monitors say at least 6,500 people have been killed in the fighting, including more than 3,200 civilians.
At least 11 people have been killed and 19 injured in an air strike on a Medecins Sans Frontieres hospital in northern Yemen.
Just hours before the attack, Saudi jets targeted a civilian vehicle in the province of Ta’izz and killed two people, after their warplanes targeted a school and other locations in the northwestern province of Sa’ada, killing several civilians, many of them children.
Government forces backed by the Arab coalition began an all-out offensive in March against extremists in south Yemen, recapturing main cities they had held.
“When jets target training camps, they can not distinguish between ages”, he said, according to the news agency.
“UNICEF calls on all parties to the conflict in Yemen to respect and abide by their obligations under global law”, it said.
After a three-month pause, it resumed raids on Tuesday, less than 72 hours after United Nations envoy Ismail Ould Cheikh Ahmed announced the collapse of peace talks.
On August 2, UN Secretary General Ban Ki-moon voiced “very serious concerns” over the killing of children in Yemen.
In Washington, the State Department said it was “deeply concerned by a reported airstrike” and called on “all parties to cease hostilities immediately”, but did not specifically point to the Saudi-led coalition.
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In Saudi Arabia, five foreign residents were wounded in suspected Houthi shelling from Yemen in the Jazan border region, the civil defence agency said. The coalition said the bombing had targeted a training facility run by Yemen’s dominant Houthi movement. The residents said two civilians were killed and four others wounded when a warplane bombed a auto laden with explosives and left in a street.
